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Event Details 
Science Pop-Up Talks - Are Multidrug-Resistant Bacteria Ticking Time Bombs?
By Professor Herman Sintim, Purdue University Antibiotic discovery and development has transformed healthcare greatly, as many bacterial infections, which were once deadly can now be treated. Yet, this development has been met with the evolution of antimicrobial resistant strains, which have made antibiotic treatment for some patients ineffective. Each year millions of people are infected with antimicrobial-resistant infections, resulting in thousands of deaths. The Centers for Disease Control and Prevention (CDC) reported that on average 2 million people suffer from antibiotic-resistant infection every year, and at least 23,000 people die from these infections. Additionally, the cost to treat these infections exceeds $20 billion per year. Globally, it is projected that in the absence of new antibacterial agents, annual mortality rates could exceed 10 million by the year 2050. To combat the antibiotic resistance, the scientific community needs to come up with new strategies to kill not only bacteria that have acquired resistance genes but also develop new tactics to kill persister and biofilm-forming bacteria. Persister bacteria are growth-arrested bacteria with significantly reduced metabolism and are able to grow and multiply once the stressor is removed. Because most antibiotics target metabolism in bacteria, these conventional antibiotics are ineffective in the normally quiescent state of persisters. Bacteria in biofilms are protected from antibiotic killing. This talk will cover work done by the Sintim group, aimed at developing new-generation antibiotics that target novel targets in bacteria, which are relevant for biofilm and persister formation. Dr. Herman Sintim obtained his BS in Medicinal Chemistry from the University College London and D.Phil. in Organic Chemistry from the University of Oxford, under the guidance of Professor David Hodgson. He then performed postdoctoral research in the chemistry of natural products at the University of Oxford in the laboratory of Professor Timothy Donohoe and a second postdoctoral research in Chemical Biology investigating the rules that govern DNA replication at Stanford University in the laboratory of Professor Eric Kool. In 2006, Sintim began his independent research at the University of Maryland as an assistant professor of chemical biology and was promoted to associate professor in 2012. In 2015, he was promoted to full professor and soon afterwards accepted an offer to move his laboratory to Purdue University.
Event Type : Study Groups      
Category : Science Pop-Up Talks -- series 2
Date(s) : 04/08/2021
Day of Week : Thursday
Time : 1:00-2:30 PM
Location : Online
Instructor : Varied, see description
Fee : $10.00
Event Status : COMPLETED